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You can use any type of noodle, or even 4 cups of cooked rice.
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Substitute canned salmon, shrimp, crab, chicken or ham, or roughly a cup of leftover chopped meat for the tuna.
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Use any type of cheese you like, or skip the cheese all together.
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Mayonnaise can be used instead of the yogurt, and cream or milk instead of the evaporated milk. Do NOT use condensed milk--it's sweet. Blech.
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Celery and onion can be sauteed in butter before adding to the casserole. I like the bit of "crunch" from leaving them uncooked. Plus it's faster.
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Vegetables can be increased, changed, or left out.